Research conducted by specialists from the University of Missouri has shown that an extract derived from aged garlic is capable of slowing down the deterioration of cognitive abilities and memory associated with aging. Information about this discovery is presented in the journal *Biomedical Reports* (BioRep). Previously, scientists have noted that garlic has a positive effect on immunity, the cardiovascular system, helps control diabetes, and reduces fat deposits in the liver. The most pronounced qualities are possessed by the extract obtained from garlic that has undergone a long maturation period (at least two dozen months). According to previously published works, this concentrate effectively fights inflammatory processes in the body and reduces the number of free radicals. These highly active particles are capable of taking electrons from cells and other compounds, a process specialists call oxidative stress. Over the years, the brain becomes more susceptible to the destructive influence of oxidative stress. This is due to a reduction in the number of nerve cells, a deterioration in the ability of synapses to change (plasticity), and reduced blood supply—factors that increase the probability of developing diseases related to the degradation of nervous tissue. The authors of the scientific work hypothesized a possible protective effect of mature garlic extract on nerve cells. They decided to test this assumption on laboratory mice: the extract was added to their food for 40 weeks. The results demonstrated that the animals in the experimental group showed improved memory, the ability to acquire new information, and exploratory activity, as well as a reduced level of anxiety. Cellular analysis revealed positive changes in the hippocampus of the animals, including a decrease in the accumulation of abnormal Tau protein. Scientists believe that garlic extract could become a promising agent (nutraceutical) for preventive measures against age-related decline in cognitive function. Nevertheless, further research is needed to prove this theory and determine an adequate dosage for humans.
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