A team of scientists from Kyoto University, in collaboration with researchers from Osaka University, has developed a therapy method that allows the human body, even in adulthood and after long-term tooth loss, to initiate the growth of new teeth. In preliminary experiments, rodents and ferrets demonstrated the ability to fully restore and form complete, healthy teeth, and a clinical trial phase involving humans has now begun in Japan. The potential for natural restoration of the dentition could dramatically improve the well-being, self-esteem, and overall quality of life for a vast number of people around the world. The essence of this innovative approach lies in inhibiting (blocking) the action of the USAG-1 protein, which under normal conditions serves as a natural “brake” on the process of forming additional teeth.
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