Researchers from the University of Griffith in Australia conducted a fundamental scientific project to investigate a potential link between the condition of the nasal lining and the etiology of neurodegenerative diseases. Experiments on rodent models indicated that damage to the nasal mucosa might facilitate the invasion of pathogenic microorganisms into the central nervous system, suggesting novel avenues for comprehending the pathogenesis of neurodegenerative disorders.
The findings of this study reveal that the bacterium Chlamydia pneumoniae, often found colonizing the nasal cavity, can utilize the olfactory nerve as a route to enter the central nervous system. Once in the brain, this bacterium prompts the accumulation of beta-amyloid peptide, leading to the formation of toxic amyloid plaques, which are characteristic pathological features in Alzheimer’s disease-related neurodegeneration. These aberrant aggregates disrupt connections between neurons, triggering neuronal degradation and cognitive impairments linked to dementia.
Dr. James St. John, the lead author of the study, emphasized that this discovery constitutes the first experimental verification of Chlamydia pneumoniae‘s capacity for direct intranasal transit into the central nervous system, a fact crucial for understanding the mechanisms underlying neurodegenerative conditions, including Alzheimer’s disease.
Dr. Betsy Grunch, a co-author, pointed out that the habit of nose-picking, common in 90% of the population, could substantially elevate the risk of bacterial entry into the brain. Even minor abrasions to the mucous membrane aid the ingress of pathogens into neural tissues, potentially resulting in the onset of serious neurodegenerative pathologies.
Based on these observations, the scientists advise against causing trauma to the nose, discouraging nose-picking, and refraining from pulling out nasal hairs. To maintain good nasal hygiene, they suggest utilizing gentle methods like saline solutions designed for nasal irrigation. If the habit of nose-picking persists, strict adherence to personal hygiene protocols, including frequent hand washing and the application of antiseptic agents, should be maintained to minimize the chance of microbial invasion.
About the Author
