ITMO University scientists have developed a laser-based method for targeted immunotherapy against cancer.
ITMO University specialists have developed photothermal immunotherapy, which enables remote activation of drugs within tumors using laser pulses. This enables precise targeting of malignant cells without affecting healthy tissue.
Side effects solved
Previously, direct administration of immune activators caused an aggressive response. The new method uses microcontainers with a polymer shell and embedded gold nanorods. The laser destroys the polymer, releasing the drug only in tumors, minimizing side effects.
Efficiency of the method
In laboratory experiments, laser activation reprogrammed up to 88% of macrophages. In experiments on mice with melanoma, this figure was approximately 28% of immune cells within the tumor. This approach allows macrophages to be induced to attack the tumor rather than defend it.
Treatment Prospects
Scientists note that tumor survival depends on its influence on its environment, particularly macrophages. The new technology disrupts this link and provides selective targeting, making treatment safer and more targeted.
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