Exosome-like nanoparticles, isolated from plums, were shown to mitigate intestinal inflammation in a mouse trial. These findings are detailed in the journal Food & Function (F&F).
The scientists examined nanovesicles, measuring 100–200 nanometers, which naturally occur within the fruit tissues. In an acute colitis model induced by dextran sulfate sodium, a week of treatment with these particles aided in restoring the length of the colon, reducing epithelial damage, and normalizing the gut microbiota composition.
Furthermore, the particles led to decreased gut permeability, lower levels of inflammatory markers and oxidative stress, and offered protection to the liver against associated damage. The researchers point out that the nanovesicles exerted an effect not only locally on the gut but also on the so-called “gut-liver axis,” which is highly significant in cases of inflammatory conditions.
Since this research was conducted in animals, its outcomes necessitate validation through human clinical trials. Nevertheless, experts believe that the bioactive particles derived from common plums hold promise as a potential foundation for novel therapeutic strategies to support patients suffering from inflammatory bowel diseases.
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