At the start of 2026, researchers announced a potential breakthrough in treating knee joint ailments. Scientists managed to discover a mechanism allowing not only the reduction of joint discomfort but also the initiation of cartilage tissue restoration.
The crucial factor proved to be the protein 15-PGDH, present in human knee joints. Studies indicated that it suppresses tissue regeneration and encourages aging. It was determined that the concentration of 15-PGDH increases with age, coinciding with a rise in reports of pain and reduced knee mobility.
The investigative team devised a method for inhibiting the activity of this protein using a single injection of an experimental compound. In preclinical trials, the agent was administered to laboratory mice with damaged joints. Following the injection, the animals exhibited cartilage recovery, a decrease in the pain syndrome, and a halt in arthrosis progression.
An improvement in joint function was also recorded: the animals could once again fully load their limbs. At the early stage, scientists confirmed the safety of the medication. The acquired findings are viewed as the foundation for further clinical studies and the creation of a novel strategy for managing degenerative joint diseases.
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