Researchers at Yale University have published a comprehensive evaluation of 51 human clinical trials in the journal Nature Medicine, clarifying which longevity interventions genuinely slow biological aging. By tracking epigenetic clocks and DNA methylation biomarkers, the team found that regular physical exercise, balanced nutrition, and specific prescription medications consistently produced measurable reductions in biological age indicators. Conversely, the vast majority of popular over-the-counter anti-aging supplements failed to demonstrate significant improvements in epigenetic aging markers, offering consumers and clinicians critical evidence-based guidance on what truly works for extending healthspan.
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