The root of Polygonum multiflorum, which has been used for over a millennium in traditional Chinese medicine, may prove to be a promising therapy for androgenetic alopecia—the most common form of hair loss. This conclusion was reached by an international team of researchers. The study is published in the Journal of Holistic Integrative Pharmacy (JHIP).
Androgenetic alopecia, also recognized as male or female pattern baldness, develops gradually. Over time, hair follicles shrink and begin to produce progressively finer and shorter hairs until their growth slows or ceases entirely.
Currently, finasteride and minoxidil medications are most frequently employed to treat this condition. However, some individuals discontinue their use due to potential side effects, including sexual dysfunction with finasteride or scalp irritation with minoxidil.
The authors of the new review examined findings from laboratory experiments, clinical observations, and historical medical texts. According to their data, Polygonum multiflorum might influence several mechanisms behind hair loss development.
One primary driver of androgenetic alopecia is considered to be the hormone dihydrotestosterone (DHT), which contributes to the reduction of hair follicles. Existing evidence suggests the plant can lessen this hormone’s impact, thereby safeguarding the follicles.
Furthermore, compounds present in the root may inhibit the premature death of hair follicle cells and activate Wnt and Shh signaling pathways, which are involved in regulating tissue growth and repair.
The researchers also note the plant’s potential beneficial effect on scalp blood supply. Improved microcirculation aids in delivering oxygen and nutrients to hair follicles, creating a more conducive environment for hair growth.
The scientists emphasize, however, that the preparation method of the plant is of great importance. In traditional Chinese medicine, the root typically undergoes specific processing, which can impact both its efficacy and safety.
The authors remind us that natural origin does not guarantee the absence of adverse effects. Active plant compounds can exert significant effects on the body, and their properties depend on dosage, raw material quality, and processing method.
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