A comprehensive review of more than 350 studies suggests that reducing protein intake could have positive effects on metabolism, reduce inflammation and cellular damage, and activate pathways associated with healthier aging and longer life. The analysis, led by researchers at the University of Wisconsin-Madison, found that lower protein intake was linked to improved metabolic function and altered nutrient signaling. One key factor is fibroblast growth factor 21 (FGF21), a hormone that increases when protein intake falls; it can raise energy expenditure, improve blood sugar regulation, and reduce inflammation. However, the review also notes that higher protein intake is important for muscle preservation, especially in older adults combined with exercise. The findings highlight that the optimal protein level may vary depending on individual circumstances.
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