Creatine is considered one of the most popular sports supplements in the world. However, in recent years, scientists have been exploring its use beyond the gym. A systematic review published in the journal Brain Medicine has provided evidence that such supplements may aid in the treatment of depression.
Researchers from the University of Ottawa conducted an analysis of five randomized controlled trials carried out in countries across the Americas, Asia, and the Middle East. A total of 238 participants (average age 36, mostly women) were involved, receiving either creatine or a placebo.
Two trials involving women with depressive disorder showed a notable effect. Those who took 5 grams of creatine daily alongside the antidepressant escitalopram experienced a more significant reduction in depressive symptoms compared to the placebo group. In another experiment, adding the supplement to cognitive behavioral therapy also yielded the expected results. However, the remaining three trials demonstrated no benefits.
Yet, two participants with bipolar disorder transitioned into a state of hypomania or mania after taking creatine. This suggests that the supplement may have varying effects depending on the diagnosis.
The authors attribute this effect to the brain’s high energy demands, as it relies on the phosphocreatine system to regenerate ATP. Affective disorders disrupt creatine metabolism, and the substance may also influence dopamine and serotonin levels.
About the Author
